Epithelial inflammasomes in the defense against Salmonella gut infection

The gut epithelium prevents bacterial access to the host's tissues and coordinates a number of mucosal defenses. Here, we review function epithelial inflammasomes in infected host focus on their role defense against Salmonella Typhimurium. This pathogen employs flagella swim towards type III secretion system (TTSS) dock invade intestinal cells. Flagella TTSS components are recognized by canonical NAIP/NLRC4 inflammasome, while LPS activates non-canonical Caspase-4/11 inflammasome. relative contributions these inflammasomes, activated cell death pathways elicited defenses subject environmental control appear change along infection trajectory. It will be an important future task explain how this may enable challenges imposed diverse enteropathogens.